Journal of Pathology and Translational Medicine

Review

Primary Age-Related Tauopathy: An Elderly Brain Pathology Frequently Encountered during Autopsy: Daru Kim, Hyung-Seok Kim, Seong-Min Choi, Byeong C. Kim, Min-Cheol Lee, Kyung-Hwa Lee, Jae-Hyuk Lee; J Pathol Transl Med. 2019;53(3):159-163. Published online March 19, 2019; DOI: https://doi.org/10.4132/jptm.2019.03.14

6,261 View
204 Download
16 Web of Science
17 Crossref

Due to the progressive aging of Korean society and the introduction of brain banks to the Korean medical system, the possibility that pathologists will have access to healthy elderly brains has increased. The histopathological analysis of an elderly brain from a subject with relatively well-preserved cognition is quite different from that of a brain from a demented subject. Additionally, the histology of elderly brains differs from that of young brains. This brief review discusses primary age-related tauopathy; this term was coined to describe elderly brains with Alzheimer’s diseasetype neurofibrillary tangles mainly confined to medial temporal structures, and no β-amyloid pathology.

Citations

Citations to this article as recorded by

Significance of a positive tau PET scan with a negative amyloid PET scan
Carling G. Robinson, Jeyeon Lee, Paul H. Min, Scott A. Przybelski, Keith A. Josephs, David T. Jones, Jonathan Graff‐Radford, Bradley F. Boeve, David S. Knopman, Clifford R. Jack, Ronald C. Petersen, Mary M. Machulda, Julie A. Fields, Val J. Lowe
Alzheimer's & Dementia.2024; 20(3): 1923. CrossRef
Hippocampal synaptic alterations associated with tau pathology in primary age-related tauopathy
Meaghan Morris, Gabrielle I Coste, Javier Redding-Ochoa, Haidan Guo, Austin R Graves, Juan C Troncoso, Richard L Huganir
Journal of Neuropathology & Experimental Neurology.2023; 82(10): 836. CrossRef
Abnormal tau in amyloid PET negative individuals
Bora Yoon, Tengfei Guo, Karine Provost, Deniz Korman, Tyler J. Ward, Susan M. Landau, William J Jagust
Neurobiology of Aging.2022; 109: 125. CrossRef
Intraneuronal sortilin aggregation relative to granulovacuolar degeneration, tau pathogenesis and sorfra plaque formation in human hippocampal formation
Juan Jiang, Chen Yang, Jia-Qi Ai, Qi-Lei Zhang, Xiao-Lu Cai, Tian Tu, Lily Wan, Xiao-Sheng Wang, Hui Wang, Aihua Pan, Jim Manavis, Wei-Ping Gai, Chong Che, Ewen Tu, Xiao-Ping Wang, Zhen-Yan Li, Xiao-Xin Yan
Frontiers in Aging Neuroscience.2022;[Epub] CrossRef
LATE: Nicht jede Demenz ist Alzheimer – Diskussion einer neuen Krankheitsentität am Fallbeispiel
Doreen Görß, Ingo Kilimann, Martin Dyrba, Sascha Nitsch, Bernd Krause, Stefan Teipel
Der Nervenarzt.2021; 92(1): 18. CrossRef
Alpha‐lipoic acid ameliorates tauopathy‐induced oxidative stress, apoptosis, and behavioral deficits through the balance of DIAP1/DrICE ratio and redox homeostasis: Age is a determinant factor
Elahe Zarini-Gakiye, Nima Sanadgol, Kazem Parivar, Gholamhassan Vaezi
Metabolic Brain Disease.2021; 36(4): 669. CrossRef
Implications for microglial sex differences in tau-related neurodegenerative diseases
Yasmine V. Doust, Anna E. King, Jenna M. Ziebell
Neurobiology of Aging.2021; 105: 340. CrossRef
G protein‐coupled receptor kinases are associated with Alzheimer's disease pathology
Thais Rafael Guimarães, Eric Swanson, Julia Kofler, Amantha Thathiah
Neuropathology and Applied Neurobiology.2021; 47(7): 942. CrossRef
Age and Dose-Dependent Effects of Alpha-Lipoic Acid on Human Microtubule- Associated Protein Tau-Induced Endoplasmic Reticulum Unfolded Protein Response: Implications for Alzheimer’s Disease
Elahe Zarini-Gakiye, Gholamhassan Vaezi, Kazem Parivar, Nima Sanadgol
CNS & Neurological Disorders - Drug Targets .2021; 20(5): 451. CrossRef
Primary age-related tauopathy in a Chinese cohort
Xin Wang, Lei Zhang, Hui Lu, Juan-li Wu, Hua-zheng Liang, Chong Liu, Qing-qing Tao, Zhi-ying Wu, Ke-qing Zhu
Journal of Zhejiang University-SCIENCE B.2020; 21(3): 256. CrossRef
Brain Aging, Cardiovascular Diseases, Mixed Dementia, and Frailty in the Oldest Old: From Brain Phenotype to Clinical Expression
Gianmarco Rosa, Chiara Giannotti, Lucia Martella, Federico Massa, Gianluca Serafini, Matteo Pardini, Flavio Mariano Nobili, Fiammetta Monacelli, Patricia Mecocci
Journal of Alzheimer's Disease.2020; 75(4): 1083. CrossRef
Extracellular Sortilin Proteopathy Relative to β-Amyloid and Tau in Aged and Alzheimer’s Disease Human Brains
Tian Tu, Juan Jiang, Qi-Lei Zhang, Lily Wan, Ya-Nan Li, Aihua Pan, Jim Manavis, Xiao-Xin Yan
Frontiers in Aging Neuroscience.2020;[Epub] CrossRef
A “Stress Test” of the 2018 NIA AA Research Criteria for Alzheimer’s Disease 
Helmut Hildebrandt, Andreas Kastrup, Paul Eling
Zeitschrift für Neuropsychologie.2020; 31(1): 26. CrossRef
Evaluation of a visual interpretation method for tau‐PET with 18 F‐flortaucipir
Ida Sonni, Orit H. Lesman Segev, Suzanne L. Baker, Leonardo Iaccarino, Deniz Korman, Gil D. Rabinovici, William J. Jagust, Susan M. Landau, Renaud La Joie
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring.2020;[Epub] CrossRef
Contemporary approaches to clinical diagnosis and treatment of tau-protein accumulation related multisystem degenerations
E.E. Vasenina, O.S. Levin
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova.2020; 120(10): 22. CrossRef
Sporadic Creutzfeldt-Jakob Disease and Other Proteinopathies in Comorbidity
Eva Parobkova, Julie van der Zee, Lubina Dillen, Christine Van Broeckhoven, Robert Rusina, Radoslav Matej
Frontiers in Neurology.2020;[Epub] CrossRef
Early Dendritic Dystrophy in Human Brains With Primary Age-Related Tauopathy
Yan-Bin Shi, Tian Tu, Juan Jiang, Qi-Lei Zhang, Jia-Qi Ai, Aihua Pan, Jim Manavis, Ewen Tu, Xiao-Xin Yan
Frontiers in Aging Neuroscience.2020;[Epub] CrossRef

Original Article

An Experimental Infarct Targeting the Internal Capsule: Histopathological and Ultrastructural Changes: Chang-Woo Han, Kyung-Hwa Lee, Myung Giun Noh, Jin-Myung Kim, Hyung-Seok Kim, Hyung-Sun Kim, Ra Gyung Kim, Jongwook Cho, Hyoung-Ihl Kim, Min-Cheol Lee; J Pathol Transl Med. 2017;51(3):292-305. Published online May 10, 2017; DOI: https://doi.org/10.4132/jptm.2017.02.17

7,755 View
111 Download
5 Web of Science
6 Crossref

Abstract PDF

Background
Stroke involving the cerebral white matter (WM) has increased in prevalence, but most experimental studies have focused on ischemic injury of the gray matter. This study was performed to investigate the WM in a unique rat model of photothrombotic infarct targeting the posterior limb of internal capsule (PLIC), focusing on the identification of the most vulnerable structure in WM by ischemic injury, subsequent glial reaction to the injury, and the fundamental histopathologic feature causing different neurologic outcomes.
Methods
Light microscopy with immunohistochemical stains and electron microscopic examinations of the lesion were performed between 3 hours and 21 days post-ischemic injury.
Results
Initial pathological change develops in myelinated axon, concomitantly with reactive change of astrocytes. The first pathology to present is nodular loosening to separate the myelin sheath with axonal wrinkling. Subsequent pathologies include rupture of the myelin sheath with extrusion of axonal organelles, progressive necrosis, oligodendrocyte degeneration and death, and reactive gliosis. Increase of glial fibrillary acidic protein (GFAP) immunoreactivity is an early event in the ischemic lesion. WM pathologies result in motor dysfunction. Motor function recovery after the infarct was correlated to the extent of PLIC injury proper rather than the infarct volume.
Conclusions
Pathologic changes indicate that the cerebral WM, independent of cortical neurons, is highly vulnerable to the effects of focal ischemia, among which myelin sheath is first damaged. Early increase of GFAP immunoreactivity indicates that astrocyte response initially begins with myelinated axonal injury, and supports the biologic role related to WM injury or plasticity. The reaction of astrocytes in the experimental model might be important for the study of pathogenesis and treatment of the WM stroke.

Citations

Citations to this article as recorded by

Animal models of focal ischemic stroke: brain size matters
Blazej Nowak, Piotr Rogujski, Raphael Guzman, Piotr Walczak, Anna Andrzejewska, Miroslaw Janowski
Frontiers in Stroke.2023;[Epub] CrossRef
Motor Cortex Plasticity During Functional Recovery Following Brain Damage
Noriyuki Higo
Journal of Robotics and Mechatronics.2022; 34(4): 700. CrossRef
Neurodegeneration, Myelin Loss and Glial Response in the Three-Vessel Global Ischemia Model in Rat
Tatiana Anan’ina, Alena Kisel, Marina Kudabaeva, Galina Chernysheva, Vera Smolyakova, Konstantin Usov, Elena Krutenkova, Mark Plotnikov, Marina Khodanovich
International Journal of Molecular Sciences.2020; 21(17): 6246. CrossRef
Quantitative assessment of demyelination in ischemic stroke in vivo using macromolecular proton fraction mapping
Marina Y Khodanovich, Alena A Kisel, Andrey E Akulov, Dmitriy N Atochin, Marina S Kudabaeva, Valentina Y Glazacheva, Michael V Svetlik, Yana A Medvednikova, Lilia R Mustafina, Vasily L Yarnykh
Journal of Cerebral Blood Flow & Metabolism.2018; 38(5): 919. CrossRef
Immunosignals of Oligodendrocyte Markers and Myelin-Associated Proteins Are Critically Affected after Experimental Stroke in Wild-Type and Alzheimer Modeling Mice of Different Ages
Dominik Michalski, Anna L. Keck, Jens Grosche, Henrik Martens, Wolfgang Härtig
Frontiers in Cellular Neuroscience.2018;[Epub] CrossRef
Administration of Downstream ApoE Attenuates the Adverse Effect of Brain ABCA1 Deficiency on Stroke
Xiaohui Wang, Rongwen Li, Alex Zacharek, Julie Landschoot-Ward, Fengjie Wang, Kuan-Han Wu, Michael Chopp, Jieli Chen, Xu Cui
International Journal of Molecular Sciences.2018; 19(11): 3368. CrossRef

First
Prev
Page of 1
Next
Last

Search